AACA

AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway[1].

Product Specifications

CAS Number

[2515609-54-6]

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/aaca.html

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CNC(C1=CC=C(C=C1)C#CCNC(C)=O)=O)O

Molecular Formula

C14H14N2O4

Molecular Weight

274.27

References & Citations

[1]Yu S, et al., Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design. Eur J Med Chem. 2024 Apr 16;271:116414.