(±) -Aiphanol

(±) -Aiphanol is a newly discovered stilbenolignan analog. (±) -Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 μM) is particularly strong, while the effect on COX-2 (IC50= 9.9 μM) is relatively weak[1]. (±) -Aiphanol effectively inhibits VEGFR2 (IC50=0.92 μM) . (±) -Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±) -Aiphanol is orally active[2].

Product Specifications

CAS Number

[578020-29-8]

Product Name Alternative

Aiphanol

UNSPSC

12352005

Target

COX; VEGFR

Type

Natural Products

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/racemic-aiphanol.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](C2=CC(OC)=C(C(OC)=C2)O)OC3=CC(/C=C/C4=CC(O)=CC(O)=C4)=CC=C3O1

Molecular Formula

C25H24O8

Molecular Weight

452.45

References & Citations

[1]Kuboki A, et al. Total Synthesis of (.+-.) -Aiphanol, a Novel Cyclooxygenase-inhibitory Stilbenolignan[J]. Chemistry letters, 2003, 32 (5) : 420-421.|[2]Chen S, et al. Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2. Signal Transduct Target Ther. 2021 Dec 3;6 (1) :413.