BCN-OH

BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps[1].

Product Specifications

CAS Number

[1263166-90-0]

Product Name Alternative

Endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bcn-oh.html

Purity

99.40

Solubility

DMSO : ≥ 100 mg/mL

Smiles

[H][C@]12[C@@]([H])([C@@H]2CO)CCC#CCC1

Molecular Formula

C10H14O

Molecular Weight

150.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Li Z, et al. Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. Chem Res Toxicol. 2019 Mar 18;32 (3) :526-534.