Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MI-2-2

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1].

Product Specifications

CAS Number

1454920-20-7

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mi-2-2.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(F)CC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1

Molecular Formula

C17H20F3N5S2

Molecular Weight

415.50

References & Citations

[1]Shi A, et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood. 2012;120 (23) :4461-4469.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

MERSC-CoV Spike Protein Goat Polyclonal Antibody
AB0161-200 600 µg

MERSC-CoV Spike Protein Goat Polyclonal Antibody

Sign In for Pricing
View Details
Cytokeratin 8/18 (rKRT8.18/1346), CF640R conjugate, 0.1mg/mL
BNC402298-500 1x 500 µL

Cytokeratin 8/18 (rKRT8.18/1346), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Ice Flaker BIFL-207
BIFL-207 1 Unit

Ice Flaker BIFL-207

Sign In for Pricing
View Details
FibuLin 2 (FBLN2) (NM_001004019) Human Over-expression Lysate
LY424048 100 µg

FibuLin 2 (FBLN2) (NM_001004019) Human Over-expression Lysate

Sign In for Pricing
View Details
PTH / Parathyroid Hormone (N-Terminal) (PTH/1175), CF405S conjugate, 0.1mg/mL
BNC041175-100 1x 100 µL

PTH / Parathyroid Hormone (N-Terminal) (PTH/1175), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Frozen Tissue Sections, Lung
CS646447 5x 5 µm

Frozen Tissue Sections, Lung

Sign In for Pricing
View Details