IEM-1754
Product Specifications
UNSPSC Description
IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iem-1754.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.Br
Molecular Weight
412.25
References & Citations
[1]Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.|[2]Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.|[3]D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100547/IEM-1754-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100547/IEM-1754-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
162831-31-4
Available Sizes
Curated Selection
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