Lorundrostat
Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2].
Product Specifications
CAS Number
1820940-17-7
Product Name Alternative
MT-4129
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lorundrostat.html
Purity
99.37
Solubility
DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
CC(N[C@@H](CC1)CC[C@H]1NC(CN2CCN(CC2)C3=NN=CC(C4=CC=C(C=C4)C)=N3)=O)=O
Molecular Formula
C24H33N7O2
Molecular Weight
451.56
Precautions
H302, H315, H319
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN) . WHO Drug Information, Vol. 36, No. 2, 2022.|[2]Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 26;330 (12) :1140-1150|[3]Hideki K, et al., Novel disubstituted 1,2,4-triazine compounds. WO2015163427.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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