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Lorundrostat

Product Specifications

UNSPSC Description

Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2].

Target Antigen

Mineralocorticoid Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lorundrostat.html

Solubility

DMSO : 33.33 mg/mL (ultrasonic;adjust pH to 2 with HCl)

Smiles

CC(N[C@@H](CC1)CC[C@H]1NC(CN2CCN(CC2)C3=NN=CC(C4=CC=C(C=C4)C)=N3)=O)=O

Molecular Weight

451.56

References & Citations

[1]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.|[2]Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 26;330(12):1140-1150

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-147277/Lorundrostat-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-147277/Lorundrostat-SDS-MedChemExpress.pdf

Clinical Information

Phase 3

CAS Number

1820940-17-7

Available Sizes

Curated Selection

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