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Lorundrostat

Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2].

Product Specifications

CAS Number

[1820940-17-7]

Product Name Alternative

MT-4129

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lorundrostat.html

Purity

99.37

Solubility

DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

CC(N[C@@H](CC1)CC[C@H]1NC(CN2CCN(CC2)C3=NN=CC(C4=CC=C(C=C4)C)=N3)=O)=O

Molecular Formula

C24H33N7O2

Molecular Weight

451.56

Precautions

H302, H315, H319

References & Citations

[1]International Nonproprietary Names for Pharmaceutical Substances (INN) . WHO Drug Information, Vol. 36, No. 2, 2022.|[2]Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 26;330 (12) :1140-1150|[3]Hideki K, et al., Novel disubstituted 1,2,4-triazine compounds. WO2015163427.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-147277/Lorundrostat-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-147277/Lorundrostat-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Curated Selection

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