Margatoxin
Product Specifications
UNSPSC Description
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].
Target Antigen
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/margatoxin.html
Purity
98.44
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CNC=N4)C(O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]6CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N8[C@@H](CCC8)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]5CCCCN)=O)NC6=O)C(N[C@@H](CC(C)C)C(N9[C@@H](CCC9)C(N%10[C@H]7CCC%10)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Molecular Weight
4178.95
References & Citations
[1]Bartok A, et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K<sup>+</sup> channels. Toxicon. 2014 Sep;87:6-16.|[2]Chen YC, et al. PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids. Thromb Haemost. 2016 May 2;115(5):1010-24.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1280/Margatoxin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1280/Margatoxin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
145808-47-5
Available Sizes
Curated Selection
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