Margatoxin

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM) . Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM) . Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].

Product Specifications

CAS Number

[145808-47-5]

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/margatoxin.html

Purity

98.44

Solubility

DMSO : ≥ 2 mg/mL

Smiles

O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CNC=N4)C(O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]6CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N8[C@@H](CCC8)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]5CCCCN)=O)NC6=O)C(N[C@@H](CC(C)C)C(N9[C@@H](CCC9)C(N%10[C@H]7CCC%10)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N