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MEH-IN-1

MEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer[1].

Product Specifications

CAS Number

[2418576-06-2]

UNSPSC

12352005

Target

Epoxide Hydrolase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/meh-in-1.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(C(C1CCCC1)SCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O

Molecular Formula

C16H17F6NOS

Molecular Weight

385.37

References & Citations

[1]Bogdan Barnych, et al. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem. 2020 May 1;193:112206.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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