2-Aminoethyl diphenylborinate

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R) . 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3) . Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue[1][2][3][4][5].

Product Specifications

CAS Number

[524-95-8]

Product Name Alternative

2-APB

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Calcium Channel; CRAC Channel; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-aminoethyl-diphenylborinate.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 1.61 mg/mL (ultrasonic)

Smiles

NCCOB(C1=CC=CC=C1)C2=CC=CC=C2

Molecular Formula

C14H16BNO

Molecular Weight

225.09

Precautions

H302, H315, H319

References & Citations

[1]Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27.|[2]Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study.|[3]Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323 (2) :337-45.|[4]Sari E, et al. Protective effect of 2-APB on testicular ischemia-reperfusion injury in rats. J Urol. 2015 Mar;193 (3) :1036-41.|[5]Nicoud IB, Knox CD, Jones CM, Anderson CD, Pierce JM, Belous AE, Earl TM, Chari RS. 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293 (3) :G623-30.