2-Aminoethyl diphenylborinate
Product Specifications
UNSPSC Description
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue[1][2][3][4][5].
Target Antigen
Calcium Channel; CRAC Channel; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-aminoethyl-diphenylborinate.html
Purity
99.86
Solubility
DMSO : 250 mg/mL (ultrasonic)|H2O : 1.61 mg/mL (ultrasonic)
Smiles
NCCOB(C1=CC=CC=C1)C2=CC=CC=C2
Molecular Weight
225.09
References & Citations
[1]Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27.|[2]Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study.|[3]Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45.|[4]Sari E, et al. Protective effect of 2-APB on testicular ischemia-reperfusion injury in rats. J Urol. 2015 Mar;193(3):1036-41.|[5]Nicoud IB, Knox CD, Jones CM, Anderson CD, Pierce JM, Belous AE, Earl TM, Chari RS. 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G623-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W009724/2-Aminoethyl-diphenylborinate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W009724/2-Aminoethyl-diphenylborinate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
524-95-8
Available Sizes
Curated Selection
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