Cyclopropavir
Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses[1][2][3][4][5].
Product Specifications
CAS Number
632325-71-4
Product Name Alternative
Filociclovir; ZSM-I-62; MBX-400
UNSPSC
12352005
Target
CMV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclopropavir.html
Purity
98.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OCC(/C1=C/N2C3=C(C(N=C(N)N3)=O)N=C2)(C1)CO
Molecular Formula
C11H13N5O3
Molecular Weight
263.26
References & Citations
[1]Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49 (3) :1039-45.|[2]James SH, et al. Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4682-91.|[3]Gentry BG, et al. Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells. Antimicrob Agents Chemother. 2014;58 (4) :2329-33.|[4]Kern ER, et al. Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections. Antimicrob Agents Chemother. 2004 Dec;48 (12) :4745-53. |[5]Toth K, et al. Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses. Antimicrob Agents Chemother. 2020 Oct 20;64 (11) :e01299-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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