Cyclopropavir

Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses[1][2][3][4][5].

Product Specifications

CAS Number

[632325-71-4]

Product Name Alternative

Filociclovir; ZSM-I-62; MBX-400

UNSPSC

12352005

Target

CMV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyclopropavir.html

Purity

98.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OCC(/C1=C/N2C3=C(C(N=C(N)N3)=O)N=C2)(C1)CO

Molecular Formula

C11H13N5O3

Molecular Weight

263.26

References & Citations

[1]Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49 (3) :1039-45.|[2]James SH, et al. Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4682-91.|[3]Gentry BG, et al. Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells. Antimicrob Agents Chemother. 2014;58 (4) :2329-33.|[4]Kern ER, et al. Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections. Antimicrob Agents Chemother. 2004 Dec;48 (12) :4745-53. |[5]Toth K, et al. Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses. Antimicrob Agents Chemother. 2020 Oct 20;64 (11) :e01299-20.