Carboplatin

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

Product Specifications

CAS Number

[41575-94-4]

Product Name Alternative

NSC 241240

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H317, H334, H340, H360

Target

Autophagy; DNA Alkylator/Crosslinker; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Carboplatin.html

Purity

99.98

Solubility

H2O : 8.33 mg/mL (ultrasonic)

Smiles

O=C1C2(CCC2)C(O[Pt]O1)=O.N.N

Molecular Formula

C6H12N2O4Pt

Molecular Weight

371.25

Precautions

H302+H312+H332, H317, H334, H340, H360

References & Citations

[1]Natarajan G, et al. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem Pharmacol. 1999 Nov 15;58 (10) :1625-9.|[2]Banerji U, et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol. 2008 Oct;62 (5) :769-78.|[3]Clark CC, et al. Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Mol Cancer Ther. 2012 Sep;11 (9) :1948-58.|[4]Dela Cruz FS, et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8 (1) :116.|[5]Hall MD, Telma KA, Chang KE, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74 (14) :3913-3922.