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Axitinib-13C,d3

Product Specifications

UNSPSC Description

Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

Target Antigen

PDGFR; VEGFR

Type

Isotope-Labeled Compounds

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Purity

97.80

Solubility

10 mM in DMSO

Smiles

[2H][13C]([2H])([2H])NC(C(C=CC=C1)=C1SC2=CC=C3C(/C=C/C4=CC=CC=N4)=NNC3=C2)=O

Molecular Weight

390.48

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Fenton BM, et al. The addition of AG-013736 to rractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15;67(20):9921-8.;Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83;Allen E, et al. Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 2016 May 10;15(6):1144-60.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C

Clinical Information

No Development Reported

CAS Number

1261432-00-1

Available Sizes

Curated Selection

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