Quinidine (sulfate dihydrate)

Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research[1][2][3][4].

Product Specifications

CAS Number

[6591-63-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Cytochrome P450; Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/quinidine-sulfate-dihydrate.html

Solubility

10 mM in DMSO

Smiles

O=S(O)(O)=O.[H]O[H].C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2(C)[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[0.5]

Molecular Formula

C20H24N2O2.1/2H2O4S.H2O

Molecular Weight

405.50

Precautions

P264-P270-P330-P501

References & Citations

[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.|[3]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14 (5) :311-7.|[4]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26 (4) :424-31.|[5]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.