RBN012759

RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of [1].

Product Specifications

CAS Number

[2360851-29-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rbn012759.html

Purity

99.33

Solubility

DMSO : 233.33 mg/mL (ultrasonic)

Smiles

O=C1NC(CS[C@H]2CC[C@H](O)CC2)=NC3=C1C(F)=CC(OCC4CC4)=C3

Molecular Formula

C19H23FN2O3S

Molecular Weight

378.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Schenkel L, et, al. A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. AACR Annual Meeting 2020.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP10; PARP14; PARP4; PARP7

Available Sizes

Curated Selection

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