Hispidulin

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

Product Specifications

CAS Number

[1447-88-7]

Product Name Alternative

Dinatin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Pim

Type

Natural Products

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Hispidulin.html

Purity

99.74

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(OC)C(O)=C13

Molecular Formula

C16H12O6

Molecular Weight

300.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78 (8) :1969-76.|[2]Gao H, et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69 (1) :27-34.|[3]Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69 (2) :311-7.|[4]Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15.