Adarotene

Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

Product Specifications

CAS Number

[496868-77-0]

Product Name Alternative

ST1926

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Adarotene.html

Purity

99.18

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC=C(C2=CC=C(O)C(C3(C4)CC5CC4CC(C5)C3)=C2)C=C1

Molecular Formula

C25H26O3

Molecular Weight

374.47

Precautions

H315, H319, H335

References & Citations

[1]Cincinelli R, et al. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003 Mar 13;46 (6) :909-12.|[2]Garattini E, et al. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103 (1) :194-207.