PNU-142633

PNU-142633 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy[1][2].

Product Specifications

CAS Number

[187665-65-2]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pnu-142633.html

Purity

98.6

Solubility

DMSO : 42 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(C(N)=O)C=C4)CC3)=C1)NC

Molecular Formula

C24H30N4O3

Molecular Weight

422.52

References & Citations

[1]McCall RB, et al. Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia. 2002 Dec;22 (10) :799-806.|[2]Gomez-Mancilla B, et al. Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine. Cephalalgia. 2001 Sep;21 (7) :727-32.