20 (R) -Ginsenoside Rh2

20 (R) -Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20 (R) -Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20 (R) -Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20 (R) -Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20 (R) -Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20 (R) -Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect[1][2][3][4][5][6].

Product Specifications

CAS Number

[112246-15-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; Apoptosis; DNA/RNA Synthesis; HSV; MMP; NO Synthase; Prostaglandin Receptor; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/20-r-ginsenoside-rh2.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1O[C@H]2CC[C@]3(C)[C@@]4([H])C[C@@H](O)[C@@H]5[C@@H]([C@](C)(O)CC/C=C(C)\C)CC[C@](C)5[C@@](C)4CC[C@@]3([H])C2(C)C

Molecular Formula

C36H62O8

Molecular Weight

622.87

Precautions

H302

References & Citations

[1]Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20 (R) -ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65 (2) :310-6.|[2]Kang S, et al. Antiviral activity of 20 (R) -ginsenoside Rh2 against murine gammaherpesvirus. J Ginseng Res. 2017 Oct;41 (4) :496-502.|[3]Liu X, et al. Comparative study on the antitumour activity of 20 (R) -ginsenoside Rh2 and 20 (S) -ginsenoside Rh2 from Panax ginseng against non-small cell lung cancer in vitro[J]. Pharmacognosy Magazine, 2022, 18 (80) .|[4]Kim AR, et al. Screening ginseng saponins in progenitor cells identifies 20 (R) -ginsenoside Rh2 as an enhancer of skeletal and cardiac muscle regeneration. Sci Rep. 2020 Mar 18;10 (1) :4967.|[5]Lv Q, et al. Antitumoral Activity of (20R) - and (20S) -Ginsenoside Rh2 on Transplanted Hepatocellular Carcinoma in Mice. Planta Med. 2016 May;82 (8) :705-11.|[6]Liu J, et al. 20 (R) -ginsenoside Rh2, not 20 (S), is a selective osteoclastgenesis inhibitor without any cytotoxicity. Bioorg Med Chem Lett. 2009 Jun 15;19 (12) :3320-3.