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8-OH-cAMP

8-OH-cAMP (8-Hydroxy-cAMP) is a polar, membrane-impermeable cyclic adenosine monophosphate analog that is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. As a polar PKA agonist, 8-OH-cAMP is used to study the role of cAMP in the development and progression of cardiovascular and metabolic diseases[1].

Product Specifications

CAS Number

31356-95-3

Product Name Alternative

8-Hydroxy-cAMP

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/8-oh-camp.html

Smiles

O[C@@H]1[C@H](OP2(O)=O)[C@@H](CO2)O[C@H]1N3C(O)=NC4=C3N=CN=C4N

Molecular Formula

C10H12N5O7P

Molecular Weight

345.21

References & Citations

[1]Waidmann O, et al. Inhibition of the equilibrative nucleoside transporter 1 and activation of A2A adenosine receptors by 8- (4-chlorophenylthio) -modified cAMP analogs and their hydrolytic products[J]. Journal of biological chemistry, 2009, 284 (47) : 32256-32263.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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