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Xanthomicrol

Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1[1][2][3][4][5].

Product Specifications

CAS Number

16545-23-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; Interleukin Related; NO Synthase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/xanthomicrol.html

Purity

97.68

Smiles

COC1=C(OC)C(OC)=C2C(C(C=C(C3=CC=C(O)C=C3)O2)=O)=C1O

Molecular Formula

C18H16O7

Molecular Weight

344.32

Precautions

H302, H315, H319, H335

References & Citations

[1]F. A. TOMAS-BARBERAN, et al. Epicuticular Flavonoids from Beffardia trixago and their Antifungal Fully Methylated Derivatives. Int. J. Crude Drug Res., 28 (l990), No. I, pp. 57-60.|[2]Fereshteh Jahaniani, et al. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005 Jul;66 (13) :1581-92.|[3]Shanshan Guo, et al. Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Function. 30-Apr-2018.|[4]Fatma Pinar Turkmenoglu, et al. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol. Molecules. 2015 Apr 23;20 (5) :7454-73.|[5]Shanshan Guo, et al. Identification of xanthomicrol as a major colonic metabolite of 5-demethyltangeretin in mice and their anti-inflammatory effects in lipopolysaccharide (LPS) -stimulated RAW 264.7 macrophages. Food & Function. 30-Apr-2018.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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