QL47B (TFA)
QL47B TFA, a biotinylated analogue of QL47 (HY-80003), is a potent inhibitor of BTK, with an IC50 value of 1.3 μM. QL47B TFA has anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ql47b-tfa.html
Purity
98.32
Solubility
10 mM in DMSO
Smiles
O=C(O)C(F)(F)F.O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CN(C)N=C4)C=C32)C5=CC=C6C(N(C(/C=C/CNCCOCCOCCOCCNC(CCCC[C@H]7[C@](NC(N8)=O)([H])[C@]8([H])CS7)=O)=O)CC6)=C5
Molecular Formula
C48H56F3N9O9S
Molecular Weight
992.07
References & Citations
[1]Hong Wu, et al. Discovery of a Potent, Covalent BTK Inhibitor for B‑Cell Lymphoma. ACS Chem Biol. 2014 May 16;9 (5) :1086-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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