SKF 91488 (dihydrochloride)

SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension[1][2][3][4].

Product Specifications

CAS Number

[68941-21-9]

Product Name Alternative

Homodimaprit (dihydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/skf-91488-dihydrochloride.html

Purity

98.62

Solubility

10 mM in DMSO

Smiles

N=C(N)SCCCCN(C)C.Cl.Cl

Molecular Formula

C7H19Cl2N3S

Molecular Weight

248.22

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9 (5-6) :455-60.|[2]Jochem J, et al. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54 (3) :237-44.|[3]Sekizawa K, et al. Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo. Am Rev Respir Dis. 1993 Jan;147 (1) :92-6.|[4]Tamaoki J, et al. Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase. Eur J Pharmacol. 1998 Apr 24;347 (2-3) :257-60.