SR10221
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1].
Product Specifications
CAS Number
1415321-64-0
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sr10221.html
Purity
98.96
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC=C(C=C1)C(C)(C)C)NC(C2=CC=C(C(C(C)=C3C)=C2)N3CC4=CC(O[C@@H](C)C(O)=O)=C(C=C4)Cl)=O
Molecular Formula
C33H37ClN2O4
Molecular Weight
561.11
References & Citations
[1]Sean Irwin, et al. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Nov;298 (11) :102539.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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