PTK7/β-catenin-IN-2
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM[1].
Product Specifications
CAS Number
902434-29-1
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptk7-β-catenin-in-2.html
Purity
96.96
Solubility
DMF : 25 mg/mL (ultrasonic)
Smiles
O=C(CCC1=C(C)N2N=C(C3=CC=C(Cl)C=C3)C=C2N=C1C)NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5
Molecular Formula
C30H34Cl2N6O
Molecular Weight
565.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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