Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MK-0731

MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2].

Product Specifications

CAS Number

[845256-65-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Kinesin; Lipoxygenase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mk-0731.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N(C)[C@@H](CC1)[C@H](F)CN1C)N2[C@@](C3=CC=CC=C3)(CO)C=C(C4=CC(F)=CC=C4F)C2

Molecular Formula

C25H28F3N3O2

Molecular Weight

459.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Christopher D Cox, et al. Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S) -4- (2,5-difluorophenyl) -n-[ (3R,4S) -3-fluoro-1-methylpiperidin-4-yl]-2- (hydroxymethyl) -N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J Med Chem. 2008 Jul 24;51 (14) :4239-52.|[2]Kyle Holen, et al. A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors. Invest New Drugs. 2012 Jun;30 (3) :1088-95.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Kinesin-5/Eg5/KSP

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit anti-Escherichia coli O45:K1 (strain S88/ExPEC) DCYD Polyclonal Antibody
MBS7174738 Inquire

Rabbit anti-Escherichia coli O45:K1 (strain S88/ExPEC) DCYD Polyclonal Antibody

Ask
View Details
Rabbit Polyclonal GART Antibody [DyLight 488]
NBP2-32206G 0.1 mL

Rabbit Polyclonal GART Antibody [DyLight 488]

Ask
View Details
FA83G, CT (FAM83G, Protein FAM83G) (AP) discontinued
035326-AP 200 µL

FA83G, CT (FAM83G, Protein FAM83G) (AP) discontinued

Ask
View Details
Chromosome 8 Gene Detection BioGenomicsTM FISH Kit discontinued
471614 1 Kit

Chromosome 8 Gene Detection BioGenomicsTM FISH Kit discontinued

Ask
View Details
Dhx34 (NM_027883) Mouse Recombinant Protein
TP511703 20 µg

Dhx34 (NM_027883) Mouse Recombinant Protein

Ask
View Details