GTS-21 (dihydrochloride)

GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist[1][2].

Product Specifications

CAS Number

[156223-05-1]

Product Name Alternative

DMXB-A; DMBX-anabaseine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; nAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/GTS-21-dihydrochloride.html

Purity

99.65

Solubility

DMSO : 16.5 mg/mL (ultrasonic; warming) |H2O : 50 mg/mL (ultrasonic)

Smiles

COC1=CC(OC)=CC=C1/C=C2CCCN=C\2C3=CC=CN=C3.Cl[H].Cl[H]

Molecular Formula

C19H22Cl2N2O2

Molecular Weight

381.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Briggs CA, et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997;57 (1-2) :231-241.|[2]Zhang R, et al. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. J Pharmacol Exp Ther. 2006;317 (3) :1276-1284.|[3]Mei Z, et al. α7 nAchR agonist GTS 21 reduces radiation induced lung injury. Oncol Rep. 2018;40 (4) :2287-2297.