Eprotirome

Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research[1][2].

Product Specifications

CAS Number

[355129-15-6]

Product Name Alternative

KB2115

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Eprotirome.html

Purity

99.77

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CC(NC1=CC(Br)=C(OC2=CC=C(O)C(C(C)C)=C2)C(Br)=C1)=O

Molecular Formula

C18H17Br2NO5

Molecular Weight

487.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10 (4) :e0122987.|[2]Rosalba Senese, et al. Thyroid hormone metabolites and analogues. Endocrine. 2019 Oct;66 (1) :105-114.