2-Hydroxy atorvastatin (calcium salt)

2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.

Product Specifications

CAS Number

[265989-46-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-hydroxy-atorvastatin-calcium-salt.html

Purity

98.01

Solubility

DMSO : 12.5 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4O)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC(O)=O)C=C1.[Ca].[1/2]

Molecular Formula

C33H35FN2O6.1/2Ca

Molecular Weight

594.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Borek-Dohalský V, et al. Validated HPLC-MS-MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma-pharmacokinetic study. Anal Bioanal Chem. 2006 Sep;386 (2) :275-85.