Ac-FEID-CMK
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway[1].
Product Specifications
UNSPSC
12352209
Target
Pyroptosis
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac-feid-cmk.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@@H](NC(C)=O)CC1=CC=CC=C1
Molecular Formula
C27H37ClN4O9
Molecular Weight
597.06
References & Citations
[1]Wang Z, et al. Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo. J Immunol. 2020 Apr 1;204 (7) :1929-1942.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Cancer Res. 2025 Jun 6.|J Immunol. 2025 Oct 8:vkaf154.
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