3,7-DMF
3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis[1].
Product Specifications
CAS Number
20950-52-1
UNSPSC
12352005
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/3-7-dmf.html
Purity
99.79
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C1C(OC)=C(C2=CC=CC=C2)OC3=C1C=CC(OC)=C3
Molecular Formula
C17H14O4
Molecular Weight
282.29
References & Citations
[1]Hyomin Park , et al. Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell. Free Radic Biol Med.2023, 204.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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