2'-Deoxyuridine 5'-monophosphate (disodium)

2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS) . dTMP is a nucleotide required for DNA synthesis[1].

Product Specifications

CAS Number

[42155-08-8]

Product Name Alternative

DUMP (disodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-deoxyuridine-5-monophosphate-disodium.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 233.33 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O

Molecular Formula

C9H11N2Na2O8P

Molecular Weight

352.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP) -binding Tyr-261. Biochemistry. 2006 Jun 20;45 (24) :7415-28.|[2]Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5 (6) :150015.