Isocurcumenol

Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively[1][2].

Product Specifications

CAS Number

[24063-71-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Estrogen Receptor/ERR

Type

Natural Products

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/isocurcumenol.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@]1(C2)/C(C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C)=C(C)/C

Molecular Formula

C15H22O2

Molecular Weight

234.33

Precautions

H302

References & Citations

[1]Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962.|[2]Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014