Estrone sulfate-d4 (sodium)

Estrone sulfate-d4 (sodium) is deuterium labeled Estrone sulfate (sodium) . Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS) . strone sulfate can be used for the research of breast cancer[1][2].

Product Specifications

CAS Number

[285979-80-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H350, H360

Target

Endogenous Metabolite; Estrogen Receptor/ERR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.38

Solubility

10 mM in DMSO|DMSO : 25mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[2H]C1=C(OS(=O)(O[Na])=O)C([2H])=C(CC[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC([2H])([2H])C4=O)C3=C1

Molecular Formula

C18H17D4NaO5S

Molecular Weight

376.44

Precautions

H315, H319, H335, H350, H360

References & Citations

[1]Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53 (2) :298-303.|[2]Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6) . Front Pharmacol. 2018;9:941. Published 2018 Aug 21. |[3]Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163 (4) :1329-1339. |[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.