(E/Z) -Zotiraciclib
(E/Z) -Zotiraciclib ((E/Z) -TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z) -Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer[1][2].
Product Specifications
CAS Number
937270-47-8
Product Name Alternative
(E/Z) -TG02; (E/Z) -SB1317
UNSPSC
12352005
Hazard Statement
H302
Target
CDK; FLT3; JAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-zotiraciclib.html
Purity
99.96
Solubility
DMSO : 26.5 mg/mL (ultrasonic; warming)
Smiles
CN1CC2=CC(NC3=NC(C4=CC(OCC/C=C/C1)=CC=C4)=CC=N3)=CC=C2
Molecular Formula
C23H24N4O
Molecular Weight
372.46
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; JAK2
Available Sizes
Frequently Asked Questions
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