Adavosertib (Standard)
Adavosertib (Standard) is the analytical standard of Adavosertib. This product is intended for research and analytical applications. Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
Product Specifications
CAS Number
955365-80-7
Product Name Alternative
AZD1775 (Standard) ; MK-1775 (Standard)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Reference Standards; Wee1
Type
Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adavosertib-standard.html
Purity
99.93
Smiles
O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C
Molecular Formula
C27H32N8O2
Molecular Weight
500.60
Precautions
H315, H319, H335
References & Citations
[1]Hirai H, et al. MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-FU. Cancer Biol Ther. 2010 Apr;9 (7) :514-22.|[2]Bridges KA, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011 Sep 1;17 (17) :5638-48. Epub 2011 Jul 28.|[3]Rajeshkumar NV, et al. MK-1775, a potent Wee1 inhibitor, synergizes with NSC 613327 to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.Clin Cancer Res. 2011 May 1;17 (9) :2799-806. Epub 2011 Mar 9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
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