Tyrphostin AG 879
Product Specifications
UNSPSC Description
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity[1][2][3].
Target Antigen
Apoptosis; EGFR; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tyrphostin-AG-879.html
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
Molecular Weight
316.46
References & Citations
[1]Zhou Y, et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11.|[2]Levitzki A, et al. Tyrosine kinase inhibition: an approach to drug development. Science. 1995 Mar 24;267(5205):1782-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-20878/Tyrphostin-AG-879-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-20878/Tyrphostin-AG-879-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
148741-30-4
Available Sizes
Curated Selection
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