VU0453379

VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].

Product Specifications

CAS Number

[1638646-27-1]

Product Name Alternative

AM152 (sodium),AZD-3355 (napadisylate)

UNSPSC

12352005

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/vu0453379.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC[C@H]1N(CCC1)C(C)C)C(C2=C3N(C4=C2C=CC=C4)C)=CN(C3=O)C5CCCC5

Molecular Formula

C26H34N4O2

Molecular Weight

434.57

References & Citations

[1]Morris LC, et al. Discovery of (S) -2-cyclopentyl-N- ((1-isopropylpyrrolidin2-yl) -9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM) . J Med Chem. 2014 Dec 11;57 (23) :10192-7.