S-Bioallethrin

S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils[1][2][3][4].

Product Specifications

CAS Number

[28434-00-6]

Product Name Alternative

D-Trans-Allethrin; Esbiol

UNSPSC

12352211

Hazard Statement

H302, H332, H410

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-bioallethrin.html

Purity

98.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C\[C@@H]1[C@H](C1(C)C)C(O[C@@H]2C(C)=C(C(C2)=O)CC=C)=O

Molecular Formula

C19H26O3

Molecular Weight

302.41

Precautions

H302, H332, H410

References & Citations

[1]McCavera SJ, et al. Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin. Neurotoxicology. 2012;33 (3) :384-390.|[2]Diel F, et al. In vitro effects of the pyrethroid S-bioallethrin on lymphocytes and basophils from atopic and nonatopic subjects. Allergy. 1998 Nov;53 (11) :1052-9. |[3]Tan J, et al. Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na (v) 1.6 sodium channels. Toxicol Appl Pharmacol. 2010 Sep 15;247 (3) :229-37.|[4]Ray DE, Burr SA, Lister T. The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats. Toxicol Appl Pharmacol. 2006 Oct 15;216 (2) :354-62.