FN-1501
FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.
Product Specifications
CAS Number
1429515-59-2
Product Name Alternative
LT-171-861
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; FLT3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FN-1501.html
Purity
98.72
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=NNC=C1NC2=NC=NC3=C2C=CN3)NC4=CC=C(CN5CCN(C)CC5)C=C4
Molecular Formula
C22H25N9O
Molecular Weight
431.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang Y, et al. Discovery of 4- ((7H-Pyrrolo[2,3-d]pyrimidin-4-yl) amino) -N- (4- ((4-methylpiperazin-1-yl) methyl) phenyl) -1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61 (4) :1499-1518.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK2; CDK4; CDK6
Available Sizes
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