Alamandine

Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].

Product Specifications

CAS Number

[1176306-10-7]

UNSPSC

12352209

Target

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alamandine.html

Purity

99.9

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

CC[C@H](C)[C@@H](C(N[C@@H](CC1=CN=CN1)C(N2CCC[C@H]2C(O)=O)=O)=O)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C)N)=O)=O)=O)=O

Molecular Formula

C40H62N12O9

Molecular Weight

855.00

References & Citations

[1]Daniel C Villela, et al. Alamandine: a new member of the angiotensin family. Curr Opin Nephrol Hypertens. 2014 Mar;23 (2) :130-4.|[2]Johanna Schleifenbaum. Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System. Front Med (Lausanne) . 2019 Jun 11;6:107.|[3]Chi Liu, et al. Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats. Amino Acids. 2018 Aug;50 (8) :1071-1081.