LY3056480
LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals[1].
Product Specifications
CAS Number
2064292-78-8
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ly3056480.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C([C@@H](C(C=C3N2CCC3(C)C)=O)NC([C@@H](NC(CCC(F)(F)F)=O)C)=O)C=C1
Molecular Formula
C23H28F3N3O4
Molecular Weight
467.48
References & Citations
[1]Schilder AGM, et al. A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. Nat Commun. 2024 Mar 1;15 (1) :1896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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