Clobenpropit (dihydrobromide)
Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR[1]. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM) . Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM) [2]. Clobenpropit dihydrobromide increases apoptosis[3].
Product Specifications
CAS Number
[145231-35-2]
UNSPSC
12352005
Target
Apoptosis; Histamine Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clobenpropit-dihydrobromide.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N=C(SCCCC1=CN=CN1)NCC2=CC=C(Cl)C=C2.[H]Br.[H]Br
Molecular Formula
C14H19Br2ClN4S
Molecular Weight
470.65
References & Citations
3
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; H2 Receptor; H3 Receptor; H4 Receptor
Available Sizes
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