(R) -Casopitant
(R) -Casopitant ((R) -GW679769) is the isomer of Casopitant. Casopitant is a NK (1) -receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].
Product Specifications
CAS Number
414910-26-2
Product Name Alternative
(R) -GW679769
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-casopitant.html
Concentration
10mM
Purity
98.60
Solubility
DMSO : ≥ 50 mg/mL
Smiles
C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)C[C@H](N4CCN(CC4)C(C)=O)CC2)=O
Molecular Formula
C30H35F7N4O2
Molecular Weight
616.61
References & Citations
[1]Di Fabio, Romano, et al. Discovery and Biological Characterization of (2R,4S) -1'-Acetyl-N-{ (1R) -1-[3,5-bis (trifluoromethyl) phenyl]ethyl}-2- (4-fluoro-2-methylphenyl) -N-methyl-4,4'-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate. Journal of Medicinal Chemistry (2011), 54 (4), 1071-1079. |[2]Christina Ruhlmann, et al. Casopitant: a novel NK (1) -receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag. 2009 Apr;5 (2) :375-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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