(R) -Casopitant

(R) -Casopitant ((R) -GW679769) is the isomer of Casopitant (HY-14405) . Casopitant is a NK (1) -receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].

Product Specifications

CAS Number

[414910-26-2]

Product Name Alternative

(R) -GW679769

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-casopitant.html

Concentration

10mM

Purity

98.60

Solubility

DMSO : ≥ 50 mg/mL

Smiles

C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)C[C@H](N4CCN(CC4)C(C)=O)CC2)=O

Molecular Formula

C30H35F7N4O2

Molecular Weight

616.61

References & Citations

[1]Di Fabio, Romano, et al. Discovery and Biological Characterization of (2R,4S) -1'-Acetyl-N-{ (1R) -1-[3,5-bis (trifluoromethyl) phenyl]ethyl}-2- (4-fluoro-2-methylphenyl) -N-methyl-4,4'-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate. Journal of Medicinal Chemistry (2011), 54 (4), 1071-1079. |[2]Christina Ruhlmann, et al. Casopitant: a novel NK (1) -receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag. 2009 Apr;5 (2) :375-84.