Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Thiamine (hydrochloride)

Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7].

Product Specifications

CAS Number

67-03-8

Product Name Alternative

Thiamine chloride (hydrochloride) ; Vitamin B1 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Keap1-Nrf2; NF-κB; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Thiamine_hydrochloride.html

Purity

99.99

Solubility

DMSO : 6.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC1=C(CCO)SC=[N+]1CC2=CN=C(C)N=C2N.[Cl-].Cl

Molecular Formula

C12H18Cl2N4OS

Molecular Weight

337.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110 (36) :14622-7.|[2]Liu X, et al. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun 16;23 (6) :1464.|[3]Hanberry BS, Berger R, Zastre JA. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol. 2014 Mar;73 (3) :585-94. |[4]Avena R, et al. Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Ann Vasc Surg. 2000 Jan;14 (1) :37-43. |[5]Nasir A, et al. Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice. Arabian Journal of Chemistry, 2024, 17 (1) : 105350. |[6]Zaringhalam J, et al. Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis. Basic Clin Neurosci. 2016 Oct;7 (4) :331-340.|[7]Dalayeli N, et al. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats. Int J Prev Med. 2024 Nov 28;15:61.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

TLR4

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PSMB5 / MB1 Rabbit Polyclonal Antibody
HA500533 100 µL

PSMB5 / MB1 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
beta-Cyclodextrin Sulfobutyl Ethers, Sodium Salts
TRC-C987845-1G 1 g

beta-Cyclodextrin Sulfobutyl Ethers, Sodium Salts

Sign In for Pricing
View Details
Genomic DNA Isolation Kit-250p
24770 250 Preparations

Genomic DNA Isolation Kit-250p

Sign In for Pricing
View Details
Fenbuconazole-lactone A R-9129
TRC-T767725-1MG 1 mg

Fenbuconazole-lactone A R-9129

Sign In for Pricing
View Details
ZNF35 Mouse Monoclonal Antibody [Clone ID: OTI1D9]
CF807031 100 µg

ZNF35 Mouse Monoclonal Antibody [Clone ID: OTI1D9]

Sign In for Pricing
View Details
4-1BBL Recombinant Rabbit Monoclonal Antibody [JE33-91]
HA721357 100 µL

4-1BBL Recombinant Rabbit Monoclonal Antibody [JE33-91]

Sign In for Pricing
View Details