Thiamine (hydrochloride)

Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[67-03-8]

Product Name Alternative

Thiamine chloride (hydrochloride) ; Vitamin B1 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Keap1-Nrf2; NF-κB; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Thiamine_hydrochloride.html

Purity

99.99

Solubility

DMSO : 6.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC1=C(CCO)SC=[N+]1CC2=CN=C(C)N=C2N.[Cl-].Cl

Molecular Formula

C12H18Cl2N4OS

Molecular Weight

337.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110 (36) :14622-7.|[2]Liu X, et al. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun 16;23 (6) :1464.|[3]Hanberry BS, Berger R, Zastre JA. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol. 2014 Mar;73 (3) :585-94. |[4]Avena R, et al. Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Ann Vasc Surg. 2000 Jan;14 (1) :37-43. |[5]Nasir A, et al. Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice. Arabian Journal of Chemistry, 2024, 17 (1) : 105350. |[6]Zaringhalam J, et al. Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis. Basic Clin Neurosci. 2016 Oct;7 (4) :331-340.|[7]Dalayeli N, et al. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats. Int J Prev Med. 2024 Nov 28;15:61.